RAF Typhoon FGR4s have joined forces with French aircraft in a combined operation on an underground arms cache in Syrian territory operated by the IS group, according to the UK's MoD.
The site, pinpointed through reconnaissance, was believed to be storing arms and explosives, the release indicated, and was situated in mountainous terrain just north of the historic site of Palmyra in the heart of Syria.
"The RAF jets used precision-guided Paveway IV munitions to hit a number of approach shafts down to the facility... preliminary assessments are that the strike was effective," officials stated.
There was no sign of any harm to civilians in the operation on Saturday evening and all the aircraft returned to base without incident, the defence officials confirmed.
The British jets were backed up by a Voyager tanker plane.
Daesh - alternatively referred to as the so-called Islamic State - imposed militant control over large swathes of Iraq and Syria before its territorial defeat in 2019.
"This action underscores the UK's leading role, and determination to stand shoulder to shoulder with allied nations, to eliminate any revival of the terrorist group and their violent and radical beliefs in the area," UK Defence Secretary the Defence Secretary said.
RAF aircraft have conducted patrols over Syria to "prevent any attempted resurgence" of IS following its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I want to thank the personnel of the UK armed forces who took part in this strike for their expertise and their courage," the Defence Secretary added. "Including them were a great many British troops on duty over the holidays. This operation, to eliminate militants who endanger our safety, demonstrates how British military are ready to step up, all year round, protecting the UK within its borders and powerful internationally."
During December, the United States armed forces executed what it called a "large-scale strike" targeting Islamic State objectives in the country, following an assault killed two US troops and a civilian linguist in Palmyra.
The United Nations estimates IS still boasts roughly 5-7 thousand fighters in Syria and Iraq.